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Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations - Nature Genetics
3+ hour, 39+ min ago (1689+ words) Nature Genetics (2026)Cite this article Taylor, H. S. , Kotlyar, A. M. & Flores, V. A. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397, 839852 (2021). Missmer, S. A. et al. Impact of endometriosis on life-course potential: a narrative review. Int. J. Gen. Med. 14, 925 (2021). Saha, R. et al. Heritability of…...
Targeting adipocyte ESRRA alleviates osteoarthritis via interrupting inter-organelle crosstalk of complement C3-CFD-MAC cascade - Bone Research
7+ hour, 1+ min ago (1701+ words) Fixed cells were stained with "-galactosidase ("-gal) dye for 48h using the "-gal Staining Kit (Solarbio #G1580). After washing three times with PBS, the stained cells were observed under a phase-contrast microscope in PBS to determine the percentage of positive cells relative…...
Risk of cerebrovascular and cardiovascular outcomes in patients with an ICD code for ocular migraine - Eye
9+ hour, 39+ min ago (408+ words) Eye (2026)Cite this article It is unknown if ocular migraine patients have an increased risk of cerebrovascular disease. This study aimed to determine if cerebrovascular and cardiovascular events were elevated among those with ocular migraine compared to controls. Patients with…...
An in vitro collagen gel contraction assay to assess the relaxing effect of potential pharmacological alternatives to oxytetracycline on foals" tendons - Scientific Reports
3+ day, 22+ hour ago (73+ words) Scientific Reports, Article'number:' (2026) Cite this article The authors thank Monica Venner (PD Dr. med. vet. , Ph D, Dipl. ECEIM, Equine Clinic Destedt, Germany) and the Gest't Lewitz, Germany, for their assistance in the collection of specimens as well as Caroline…...
Author Correction: A "-opioid receptor superagonist analgesic with minimal adverse effects
5+ day, 12+ hour ago (171+ words) The Original Article was published on 01 April 2026 Drug Design and Synthesis Section, Molecular Targets and Medication Discovery Branch, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, USA Department of Molecular and Cellular Physiology, Stanford University School of Medicine,…...
Impact of music on pain perception during office-based transperineal prostate biopsy: a prospective non-randomized study - Scientific Reports
5+ day, 10+ hour ago (637+ words) That said, TP PBx is still associated with greater perceived pain compared to the TR approach, despite adequate sedation or anesthesia5. This factor not only negatively affect the patient's experience and their willingness to undergo repeat procedures, but also limit the…...
Sabinineoside B alleviates metabolic dysfunction-associated steatotic liver disease by targeting PPAR " - Communications Biology
1+ week, 1+ day ago (1116+ words) Powell, E. E. , Wong, V. W. & Rinella, M. Non-alcoholic fatty liver disease. Lancet 397, 22122224 (2021). Rinella, M. E. et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology 78, 19661986 (2023). Barbara, G. , Michal, P. , Philippe, L. & Bart, S. PPARs in obesity-induced T2 DM, dyslipidaemia and NAFLD. Nat. Rev. Endocrinol. 13, 3649 (2016). Venteclef, N. , Jakobsson, T. , Steffensen,…...
Adult Intussusception: Diagnosis, Management, and Case Studies
9+ mon, 1+ week ago (366+ words) Adult intussusception represents a rare yet clinically significant condition that differs markedly from its paediatric counterpart. In adults, the phenomenon generally arises due to a pathological. .. Adult Intussusception: Diagnosis, Management, and Case Studies Adult intussusception represents a rare yet clinically…...
Overcoming roadblocks to anti-inflammatory NLRP3 inhibitors
7+ mon, 1+ week ago (208+ words) The NLRP3 inflammasome is an essential component of the innate immune response, mediating caspase-1 activation, the secretion of the proinflammatory cytokines interleukin (IL)-1" and IL-18 and. .. Thank you for visiting nature. com. You are using a browser version with limited support for CSS....
Chronic Pelvic Pain Syndrome and Prostatitis
9+ mon, 1+ week ago (468+ words) Chronic pelvic pain syndrome (CPPS) and prostatitis represent a complex spectrum of disorders characterised by persistent discomfort, inflammation and urinary dysfunction. While they may share. .. Chronic Pelvic Pain Syndrome and Prostatitis Chronic pelvic pain syndrome (CPPS) and prostatitis represent a…...