10+ hour, 44+ min ago  (334+ words) Rheumatoid arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality, partly related to chronic systemic inflammation and accelerated atherosclerosis. Janus kinase (JAK) inhibitors, including baricitinib, are effective targeted therapies for RA, but their use in older patients and those…...

1+ day, 9+ min ago  (216+ words) Intussusception in adults is an uncommon cause of intestinal obstruction and is usually associated with an underlying structural lesion, unlike pediatric cases. In most adult patients, a pathological lead point is identified, frequently neoplastic in origin, making surgical management the…...

23+ hour, 49+ min ago  (243+ words) A patient complained of left-sided low back pain that radiated to her left ankle and, upon examination, was found to have right hip internal rotation weakness. She was classified by this author as having a directional preference for lumbar rotation…...

1+ day, 1+ hour ago  (300+ words) Introduction: Postoperative pain following Chiari malformation decompression is frequently severe and may contribute to substantial postoperative healthcare utilization. Although multimodal analgesic strategies are increasingly utilized across surgical specialties, postoperative pain management practices following Chiari decompression remain variable and poorly characterized....

1+ day, 6+ hour ago  (255+ words) Symptomatic thoracic disc herniation (TDH) is a rare entity, accounting for less than 4% of all surgically treated disc herniations, yet it can produce devastating myelopathy because of the precarious vascular supply and limited anatomic reserve of the thoracic spinal cord....

1+ day, 3+ hour ago  (212+ words) Pain is highly prevalent among patients with advanced cancer and often remains refractory to optimized systemic analgesia. When opioid therapy fails or causes intolerable side effects, interventional techniques may offer improved symptom control and quality of life. We report the…...

1+ day, 8+ hour ago  (135+ words) A 91-year-old woman with chronic tophaceous gout presented with worsening left foot pain, swelling, and purulent drainage after several months of presumed gout flares treated with prednisone and antibiotics. At presentation, she was septic with leukocytosis, elevated inflammatory markers, and…...

1+ day, 10+ hour ago  (376+ words) Background: Cerebral palsy (CP) at GMFCS level II is the most functionally heterogeneous ambulatory group, with high intra-group variability in walking endurance and daily physical activity. The relationship between six-minute walk test (6 MWT) outcomes and accelerometer-based monitoring following inpatient rehabilitation…...

2+ day, 13+ hour ago  (236+ words) Cervical spondylotic myelopathy (CSM) is a common clinical syndrome caused by degenerative changes of the cervical spine and frequently presents with lower extremity dysfunction. However, the relationship between specific cervical levels and lower extremity functional impairment remains unclear. This retrospective…...

1+ day, 19+ hour ago  (312+ words) Background: Knee osteoarthritis (KOA) is a common musculoskeletal condition that markedly reduces patients" quality of life and places an increasing burden on healthcare systems. Biotherapy has anti-inflammatory and tissue-reparative effects but does not adequately address KOA-related biomechanical or functional impairments....