2+ day, 17+ hour ago  (158+ words) A systematic review found Janus kinase inhibitor monotherapy improved outcomes vs methotrexate or placebo, but direct comparisons with combination therapy were limited. Baricitinib also improved outcomes compared with placebo among patients with inadequate response to methotrexate. In one phase 3 trial,…...

2+ day, 17+ hour ago  (212+ words) Ten-year observational data showed lower disease activity and functional disability coinciding with broader use of biologic and targeted synthetic therapies. Patients with rheumatoid arthritis had improved disease activity and functional disability measures over 10 years in a single-center Japanese cohort, coinciding…...

3+ day, 11+ hour ago  (346+ words) Conexiant Neuroimaging could help separate patients with migraine into two subgroups with distinct clinical and imaging profiles In a study, researchers analyzed structural and resting-state functional magnetic resonance imaging (MRI) data from 111 patients with migraine and 51 controls The migraine cohort…...

3+ day, 13+ hour ago  (395+ words) Supervised rehabilitation and exercise-based therapies may improve function, pain, and bone health in ankylosing spondylitis, according to a new review. Patients with ankylosing spondylitis face substantially elevated risks of vertebral, hip, and other fractures as progressive spinal rigidity and kyphosis…...

2+ week, 2+ day ago  (234+ words) Amputation rates increased among US adult opioid-related hospitalizations from 2016 to 2022, with steeper increases than those observed among nonopioid-related hospitalizations, according to a brief research report published in Annals of Internal Medicine. In adjusted analyses, the excess increase was statistically evident…...

2+ week, 2+ day ago  (297+ words) The review included nine studies with 24, 643 patients, comprising six randomized controlled trials and three cohort studies. However, the patient count was heavily influenced by observational data; one retrospective cohort study contributed 14, 891 patients, representing more than half of the pooled population....

2+ week, 4+ day ago  (424+ words) At 5 years, 63% of patients in the Cli DR group maintained sustained remission compared with 38% in the non-Cli DR group. Patients with rheumatoid arthritis who achieved clinical deep remission were more likely to maintain long-term remission and appeared less vulnerable to…...

2+ week, 4+ day ago  (378+ words) The researchers analyzed six items from the MD Anderson Symptom Inventory'Head and Neck module: chewing or swallowing difficulty, choking, speech or voice changes, mucus, fatigue, and dry mouth. These items were averaged to create the MDASI-HN-NERVE score, a composite intended…...

2+ week, 6+ day ago  (247+ words) Patients recovering from repair surgery for acute Achilles tendon rupture who used weight-bearing mobility aids may achieve quicker functional recovery but could experience higher rates of complications compared with those using non'weight-bearing devices, according to a prospective cohort study. Weight-bearing…...

1+ mon, 3+ day ago  (324+ words) Early improvements in pain, sleep, and mobility were not sustained and weakened after age adjustment in a randomized trial. Low-dose oral prednisolone added to celecoxib following total knee arthroplasty was associated with lower early postoperative pain, but benefits were attenuated…...