3+ day, 13+ hour ago   (465+ words) Epidermal growth factor receptors (EGFR) are supposed to help your cells grow and divide. When this gene mutates, it can get stuck producing new cells, leading to abnormal cell growth, otherwise known as cancer. It’s a significant risk factor for…...

4+ day, 19+ hour ago   (292+ words) When a patient with decision-making capacity declines immediate excision of a lesion on her foot despite strong suspicion of acral melanoma, the appropriate response is to balance the patient’s autonomy with the clinician’s duty to act on the suspected malignancy,…...

5+ day, 9+ hour ago   (600+ words) The medication didn’t work.” Nearly every clinician who manages chronic disease has heard some version of this statement. Sometimes treatment truly fails. Sometimes disease progresses despite appropriate therapy. But often the issue is more subtle: a gap between what the…...

1+ week, 1+ day ago   (96+ words) Paras Karmacharya, MD, MS This content was created in collaboration with AbbVie. Paras Karmacharya, MD, discusses how switching treatment mechanisms after initial therapy failure significantly improved low disease activity and remission rates versus cycling therapies at 12 weeks. Despite these gains,…...

1+ week, 4+ day ago   (536+ words) Physician's Weekly Q&A: Neighborhood Social Vulnerability Influences Colon Cancer Trial Enrollment for Younger Patients Young adults with colon cancer demonstrated higher enrollment in clinical trials, but their odds of enrollment were more negatively influenced by neighborhood social vulnerability compared with…...

1+ week, 4+ day ago   (655+ words) In their broad overview, the researchers explain how optimized tissue handling, appropriate test selection, and interdisciplinary collaboration can improve outcomes for patients with NSCLC, which accounts for almost 85% of all lung cancer cases. Physician’s Weekly spoke with Michael Grant, MD,…...

1+ week, 4+ day ago   (174+ words) Patient-Level Factors Drive Treatment Intensification Decisions in De Novo mHSPC In the complete cohort, most of the variation in treatment intensification was attributable to patient characteristics. Patients who were older had lower odds of intensification, as did patients who were…...

2+ week, 3+ day ago   (89+ words) Beyond Fit/Unfit: A CLL Treatment Framework for Patients Aged ≥80 Patients aged 80 years and older are excluded from most chronic lymphocytic leukemia (CLL) clinical trials, and traditional frailty assessment tools often fail to identify key age-related vulnerabilities. Given these limitations,…...

2+ week, 5+ day ago   (80+ words) Identifying Candidates for Endoscopic Resection in Early Gastric Cancer A meta-analysis of 101 studies, published in the World Journal of Surgical Oncology, identified factors associated with lymph node (LN) metastasis in early gastric cancer, which could help inform the choice between…...

2+ week, 5+ day ago   (64+ words) Supporting Physical Function, QOL During Lung Cancer Treatment A study published in Current Oncology reported that personalized PR during active lung cancer treatment was feasible, safe, and associated with improvements in cancer-related fatigue. Immunization Awareness Month: Strategies to Address Vaccine…...