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The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel - Acta Pharmacologica Sinica
4+ day, 14+ hour ago (1854+ words) Rapport MM, Green AA, Page IH. Serum vasoconstrictor, serotonin; isolation and characterization. J Biol Chem. 1948;176:124351. Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, et al. International union of basic and clinical pharmacology. CX. Classification of receptors for…...
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience
5+ day, 15+ hour ago (1698+ words) To establish the importance of TRKA+ sensory neurons, we crossed TrkACreERT2 mice with Ai40 (ArchT) mice to silence TRKA+ neurons (TrkAArchT). Optogenetic inhibition reversed allodynia and pricking and cold hyperalgesia, as well as joint pain behavior, limb dysfunction and paw dexterity deficits…...
PRMT6 is required for initiating and amplifying macrophage-induced inflammation in heterotopic ossification by increasing CCL2 expression - Bone Research
5+ day, 19+ hour ago (1682+ words) Upregulation of PRMT6 in macrophages during trauma/burn injury. a Volcano plot showing differentially expressed genes (fold change>2, q Collectively, these findings identify PRMT6 as a macrophage-enriched inflammatory regulator during the early phase of TBI-induced HO, supporting its potential role as a…...
Triazole 187 is a biased KOR agonist that suppresses itch without sedation and induces anxiolytic-like behaviors in mice - Neuropsychopharmacology
6+ day, 10+ hour ago (1774+ words) Cell membranes are prepared from CHO-hKOR cells and assessed for [35S]-GTP'S binding following treatment with KOR agonists according to previously published protocols [32, 34]. Two technical replicates were included in each individual experiment (n3). A The distance traveled in male C57BL6/J is rapidly…...
About the Guest Editors | Cartilage biology
1+ week, 2+ day ago (240+ words) About the Guest Editors | Cartilage biology'Nature Your privacy, your choice We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media, as well as to…...
Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis - Experimental & Molecular Medicine
1+ week, 3+ day ago (1575+ words) To induce apoptosis in chondrocytes, an essential pathological feature in OA, the cells were treated with 10ngml of tumor necrosis factor (TNF) recombinant protein (Ag11413, Proteintech) for 24h. Alongside the induction of inflammation and apoptosis, ATDC5 cells were concurrently infected with AAV-OSK or AAV-Mock....
Intensive longitudinal brain imaging reveals personalized signatures of chronic pain - Nature Neuroscience
1+ week, 3+ day ago (169+ words) Davis, K. D. et al. Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities. Nat. Rev. Neurol. 16, 381400 (2020). A consensus statement that provides guidance for the discovery and validation of pain biomarkers. Tracey, I. Neuroimaging…...
40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway - Cell Research
1+ week, 4+ day ago (1733+ words) Cell Research (2026)Cite this article To determine whether extending daily exposure would enhance analgesia, we increased the stimulation to 4h each in the morning and evening (8h/day). However, the analgesic efficacy was comparable to that observed with the 2-h daily regimen…...
Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages - Cellular & Molecular Immunology
1+ week, 4+ day ago (1781+ words) Cellular & Molecular Immunology (2026)Cite this article Overall, our results indicate that GM-CSFR/" M's in RA synovial tissue respond to tofacitinib by promoting regulatory and oxidative repair genes, while suppressing inflammatory and glycolytic pathways via STAT5 deactivation. Human IL1, IL6, CCL2, and IL10 protein levels were…...
Paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component in treatment of neuropathic pain after incomplete spinal cord injury – a pilot trial - Spinal Cord Series and Cases
1+ week, 5+ day ago (1724+ words) Spinal Cord Series and Cases volume12, Articlenumber:3 (2026) Cite this article Clinically significant relief in pain was not achieved with high-PAS or sham treatment. Expectations for treatment were screened with questionnaires before sham- and high-PAS periods. This questionnaire assessed the anticipation of…...