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A Mechanistic Explanation for SIRT1’s Effects
1+ week, 6+ day ago (659+ words) Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. Sirtuins have been heavily researched in the context of aging. SIRT6 has been specifically identified as…...
How Old Fat Cells Trigger Inflammation and Raise Risks
3+ week, 3+ day ago (336+ words) Using cohort studies and a mouse model, researchers have found that the circulating factor ANGPTL8, which is produced by senescent fat cells, is related to age-related diseases and mortality in mice and people. [2] Ou, M. Y., Zhang, H., Tan, P. C., Zhou, S. B., & Li, Q. F. (2022). Adipose tissue aging:…...