5+ day, 9+ hour ago   (488+ words) Researchers publishing in Aging Cell have described how stopping growth hormone receptor production in midlife significantly lengthens the lives of mice. Those mouse models, however, are genetically modified, with effects from birth. Bringing this into the clinic requires affecting growth…...

1+ week, 5+ day ago   (659+ words) Researchers have found that the sirtuin SIRT1 stabilizes the human genome by suppressing retrotransposition, which occurs when parts of the genome transcribe themselves onto other parts. Sirtuins have been heavily researched in the context of aging. SIRT6 has been specifically identified as…...

4+ week, 1+ day ago   (492+ words) A massive human genetics study identified rare folliculin-interacting protein 1 (FNIP1) mutations associated with favorable metabolism and much lower cardiometabolic disease risk. Experiments in human liver cells and mice suggest a therapeutic route [1]. Importantly, that does not necessarily mean that genetics contributes…...