7+ hour, 12+ min ago   (444+ words) EMJ This site is intended for healthcare professionals How Rabies Virus Infection Triggers Fatal Brain Immune Failure - Virulent rabies virus infection induces microglial stress phenotypes and severe neuroinflammation. - Fatal outcomes feature natural killer cell suppression, regulatory T cell expansion, and…...

1+ day, 7+ hour ago   (411+ words) A NEW recombinant birch pollen allergy vaccine has significantly reduced symptoms and medication use during pollen season, according to results from a first-in-human clinical trial. The findings suggest that a short course of pre-seasonal injections could provide an effective approach…...

1+ week, 3+ day ago   (415+ words) MOIST wound healing shortened burn donor site recovery and eased pain and psychological symptoms after skin grafting. A retrospective cohort study of 173 adults found that a moisture preserving strategy was associated with faster healing, lower pain scores, and better skin…...

1+ week, 2+ day ago   (254+ words) The most successful investigation of outbreaks results from close collaboration of epidemiologists and microbiologists. Today, microbiologists can use whole genome sequencing to securely identify bacterial isolates from both patients and environmental sources as being identical, thus providing strong confirmatory evidence…...

2+ day, 7+ hour ago   (371+ words) AstraZeneca’s experimental lung disease drug has significantly reduced COPD flare-ups in two late-stage trials, strengthening the case for a potential new biologic treatment for the condition. COPD is a progressive lung disease that causes breathing difficulties, coughing and excess mucus…...

2+ day, 7+ hour ago   (415+ words) Elevated orexin accelerates cognitive decline, but deep sleep rhythms offer protection. Read more on these new clinical findings. This site is intended for healthcare professionals Why Orexin in Alzheimer Disease Demands Targeted Sleep Therapy - Elevated CSF orexin directly correlates with…...

2+ day, 7+ hour ago   (274+ words) COLORECTAL cancer research has identified a core transcriptional regulatory circuitry involving MYC, ETS2 and FOXP1 that controls cancer type specific super enhancer activity and supports expression of key genes. The study reported that the master transcription factor MYC actively regulated super enhancer…...

2+ day, 2+ hour ago   (362+ words) AbbVie’s atogepant has met the primary endpoint of the phase 3 LUNA trial, which tested the drug as a preventive treatment for menstrual migraine. In the phase 3 LUNA trial, atogepant reduced migraine days during the perimenstrual period by an average of…...

3+ day, 7+ hour ago   (244+ words) A newly funded five-year study will investigate how e-cigarette components and flavors used during pregnancy affect fetal respiratory immune development. The $2.4 million project will also examine whether exposure increases offspring susceptibility to viral infection after birth. The research addresses an…...

3+ day, 7+ hour ago   (354+ words) MOHS surgery produced smaller defects without a significant difference in five-year recurrence after cutaneous squamous cell carcinoma. A prospective multicenter cohort study compared outcomes after Mohs micrographic surgery and standard excision for primary cutaneous squamous cell carcinoma (CSCC). Although Mohs…...