16+ hour, 9+ min ago   (273+ words) An expert panel moderated by Sara Nunnery, MD, of Tennessee Oncology, convened to discuss how they choose therapy beyond the first-line setting for patients with ESR1-mutated disease. Dr. Nunnery was joined by Nan Chen, MD, of the University of Chicago;…...

2+ day, 11+ hour ago   (290+ words) Jeffrey Hyams, MD, of the University of Connecticut and Connecticut Children’s Hospital in Hartford, Connecticut, shares results from the UNIFI JR trial evaluating ustekinumab in pediatric patients with ulcerative colitis who did not respond to conventional therapies. From these results…...

4+ day, 19+ hour ago   (438+ words) SANRECO is a three-part, ongoing, global clinical trial to evaluate divesiran for treatment of polycythemia vera (PV). One component is a phase 2, randomized, placebo-controlled study of the agent in phlebotomy-dependent patients with disease that has withstood standard-of-care interventions. This study…...

2+ week, 3+ day ago   (689+ words) Docwire News Upadacitinib Shows Promising Efficacy for Alopecia Areata According to phase 3 data, upadacitinib may represent a potential treatment option for patients with severe alopecia areata. There is currently an unmet need for systemic therapies for alopecia areata—with only…...

2+ week, 4+ day ago   (213+ words) Huntington’s disease (HD) involves disruption in brain cholesterol homeostasis, with several HD animal models showing reduced brain cholesterol biosynthesis and levels. Providing exogenous cholesterol has been effective for improving phenotypes, but the existing methods used to deliver cholesterol are invasive…...

2+ week, 6+ day ago   (260+ words) PBH is a chronic metabolic condition that affects about 8% of people in the US following sleeve gastrectomy and Roux-en-Y gastric bypass (RYGB) surgery, the two most common types of bariatric surgery. The condition can cause severe hypoglycemia, leading to substantial…...